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ROS-induced apoptosis also explains the beneficial effect of two analogs of nuclear receptor ligands in several types of cancer: 2-methoxyestradiol, a 17-estradiol metabolite, and N-(4-hydroxyphenyl) retinamide, a synthetic analog of retinoic acid, have been shown to induce PCD in neuroblastoma and lung cancer cells, respectively 104,105

T-cell surface molecules or secreted factors may also regulate the expression of lipid-metabolic enzymes such as ACSL4, thereby indirectly fostering ferroptosis (113)

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Once a luxury reserved for the cash-pay elite, weight-loss drugs are about to be as accessible as statinsa shift that could redefine how obesity care is delivered and challenge the direct-to-consumer playbook that made it mainstream